Arsenal sent holders Milan packing from the Champions League on Tuesday as the English Premier League leaders booked a quarterfinal place with a 2-0 win at the San Siro.

Manchester United eked out a 2-1 aggregate win over French rivals Olympique Lyon, Barcelona made smooth progress at the expense of Celtic while Turkish surprise package Fenerbahce sneaked through on penalties against Sevilla.

Goals from Cesc Fabregas and Emmanuel Adebayor guided Arsenal to victory in Milan, the first by an English side against the Rossoneri at the San Siro, giving manager Arsene Wenger high hopes of lifting the trophy in May. 

Milan dominated the opening stages of a titanic tussle but Arsenal quickly found their feet and always looked more likely to score before Fabregas finally broke the deadlock with a stunning strike in the 84th minute.

The midfielder took the ball in his stride and beat Zeljko Kalac in goal with a rasping low shot from 30 metres that crept into the bottom right corner before Adebayor sealed the win from close range in injury time.

The Togo striker was left with a simple tap-in at the far post to score his first Champions League goal of the season after substitute Theo Walcott delivered a perfect low cross.

Man U struggle

English champions United were made to work hard and defend resolutely at times in a nervy 1-0 win over Olympique Lyon at Old Trafford, courtesy of Cristiano Ronaldo's 30th goal of the season in all competitions.

Barcelona completed a 4-2 aggregate win over Celtic with a 1-0 second leg win at the Nou Camp after Xavi rounded off a flowing team move with a clever flick into the top corner.

Messi injured

However, their victory was overshadowed with a new injury setback to live-wire forward Lionel Messi, who left the pitch in tears late in the first half with a thigh muscle tear in his left leg,. The club later said that Messi will be sidelined for six weeks.

Sevilla made a dramatic exit after taking a 2-0 lead against Fenerbahce through a pair of howlers by goalkeeper Volkan Demirel.

The keeper let in long-range efforts by Daniel Alves and Seydou Keita but turned hero when he denied Julien Escude, Enzo Maresca and finally Alves in the penalty shootout.   Goals by Brazilian striker Deivid either side of Frederic Kanoute's effort had made it 3-2 to Sevilla at the end of regular and extra time to tie the score 5-5 on aggregate and force a thrilling climax.