<p>Two months after Gambian authorities linked 70 paediatric deaths to cough syrups made in India, Uzbekistan has alleged that 18 children have died in the central Asian nation following the consumption of a syrup made by another Indian manufacturer.</p>.<p>"To date, 18 out of 21 children with acute respiratory disease have died as a result of taking Doc-1 Max syrup manufactured by the Indian company Marion Biotech Pvt Ltd," the Uzbekistan health ministry said in a statement.</p>.<p>"It was found that the deceased children, before admission to hospital treatment, took this drug at home for 2-7 days 3-4 times a day, 2.5-5 ml, which exceeds the standard dose of the drug for children."</p>.<p><strong>Read | <a href="https://www.deccanherald.com/national/gambia-deaths-govt-blames-who-for-premature-deduction-1172136.html" target="_blank">Gambia deaths: Govt blames WHO for premature deduction</a></strong></p>.<p>The Union health ministry sources didn't respond to <em>DH</em>'s queries on the incident. Still, they maintained that a file was placed before Health Minister Manuskh Mandaviya, who also heads the Department of Pharmaceuticals as the Minister for Chemicals & Fertilisers. Noida-based Marion Biotech also didn't respond to phone calls.</p>.<p>The press statement from the Uzbekistan Health Ministry identifies two factors behind the tragedy — excess doses of the medicine in kids who don't require the drug and contamination of ethylene glycol — one of the two toxic chemicals found in the Gambian case.</p>.<p>"All children were given the drug without a doctor's prescription. Since the main component of the drug is paracetamol, Doc-1 Max syrup was incorrectly used by parents as an anti-cold remedy on their own or the recommendation of pharmacy sellers. This was the reason for the deterioration of the condition of patients," the Uzbek ministry said.</p>.<p>Uzbekistan authorities explained paracetamol should be administered only once or twice a day if the body temperature is in the range of 38-38.5 degrees Celsius. At normal body temperature, taking this drug is strictly prohibited.</p>.<p>But the toxic contaminant was also found in the syrup.</p>.<p>"Preliminary laboratory studies have shown that this series of Doc-1 Max syrup contains ethylene glycol. This substance is toxic, and about 1-2 ml/kg of a 95% concentrated solution can cause serious changes in the patient's health, such as vomiting, fainting, convulsions, cardiovascular problems and acute kidney failure," Uzbekistan authorities said.</p>.<p>The World Health Organisation in October flagged the presence of ethylene glycol and diethylene glycol as toxic contaminants in four cough syrup samples (made by Maiden Pharmaceuticals, Haryana) that are reportedly linked to the deaths of 70 children in The Gambia. But this was not the first time EG and DEG were found in cough syrups made in India, as there have been many similar cases in the past with fatal consequences.</p>
<p>Two months after Gambian authorities linked 70 paediatric deaths to cough syrups made in India, Uzbekistan has alleged that 18 children have died in the central Asian nation following the consumption of a syrup made by another Indian manufacturer.</p>.<p>"To date, 18 out of 21 children with acute respiratory disease have died as a result of taking Doc-1 Max syrup manufactured by the Indian company Marion Biotech Pvt Ltd," the Uzbekistan health ministry said in a statement.</p>.<p>"It was found that the deceased children, before admission to hospital treatment, took this drug at home for 2-7 days 3-4 times a day, 2.5-5 ml, which exceeds the standard dose of the drug for children."</p>.<p><strong>Read | <a href="https://www.deccanherald.com/national/gambia-deaths-govt-blames-who-for-premature-deduction-1172136.html" target="_blank">Gambia deaths: Govt blames WHO for premature deduction</a></strong></p>.<p>The Union health ministry sources didn't respond to <em>DH</em>'s queries on the incident. Still, they maintained that a file was placed before Health Minister Manuskh Mandaviya, who also heads the Department of Pharmaceuticals as the Minister for Chemicals & Fertilisers. Noida-based Marion Biotech also didn't respond to phone calls.</p>.<p>The press statement from the Uzbekistan Health Ministry identifies two factors behind the tragedy — excess doses of the medicine in kids who don't require the drug and contamination of ethylene glycol — one of the two toxic chemicals found in the Gambian case.</p>.<p>"All children were given the drug without a doctor's prescription. Since the main component of the drug is paracetamol, Doc-1 Max syrup was incorrectly used by parents as an anti-cold remedy on their own or the recommendation of pharmacy sellers. This was the reason for the deterioration of the condition of patients," the Uzbek ministry said.</p>.<p>Uzbekistan authorities explained paracetamol should be administered only once or twice a day if the body temperature is in the range of 38-38.5 degrees Celsius. At normal body temperature, taking this drug is strictly prohibited.</p>.<p>But the toxic contaminant was also found in the syrup.</p>.<p>"Preliminary laboratory studies have shown that this series of Doc-1 Max syrup contains ethylene glycol. This substance is toxic, and about 1-2 ml/kg of a 95% concentrated solution can cause serious changes in the patient's health, such as vomiting, fainting, convulsions, cardiovascular problems and acute kidney failure," Uzbekistan authorities said.</p>.<p>The World Health Organisation in October flagged the presence of ethylene glycol and diethylene glycol as toxic contaminants in four cough syrup samples (made by Maiden Pharmaceuticals, Haryana) that are reportedly linked to the deaths of 70 children in The Gambia. But this was not the first time EG and DEG were found in cough syrups made in India, as there have been many similar cases in the past with fatal consequences.</p>
