The BSE benchmark Sensex fell nearly 300 points to crack below the 34,000-mark today amid weak Asian cues after a US-led strike on Syrian targets fuelled fresh geopolitical concerns.
The 30-share index fell by 293.31 points or 0.85 percent to 33,899.34 in opening trade.
The gauge had gained 1,173.88 points in the previous seven sessions.
BSE sectoral indices, led by IT, Teck, oil and gas, PSU, power, infrastructure and banking stocks, declined up to 1.45 percent.
The NSE Nifty was lower by 84.25 points, or 0.80 percent, at 10,396.35.
Shares of Infosys fell 3.86 percent to Rs 1,123.90 less-than-expected FY19 revenue guidance. The stock was the biggest contributor to the losses on Sensex.
Other major losers were Tata Motors, Wipro, Axis Bank, ONGC, NTPC, RIL, Dr Reddy's SBI, Bharti Airtel, ICICI Bank, Maruti Suzuki, Asian Paint and Tata Steel, falling by up to 1.54 percent.
Among other Asian markets, Hong Kong's Hang Seng shed 1.44 percent, while Shanghai Composite Index was down 1.05 percent in early trade. Japan's Nikkei, however, was up 0.26 percent.
The US Dow Jones Industrial Average ended 0.50 percent lower in Friday's trade.