The chemistry helped them make 1.8 billion pounds at the box office, reported thesun.co.uk.
The second hottest pair was Kristen Dunst and Tobey Maguire who made 1.5 billion pounds for the three "Spiderman" film.
Forbes magazine, which compiled the list, included couples that were in at least two films together.
Kate Winslet and Leonardo Dicaprio came third, with 1.1 billion for "Titanic" and 50 million pounds for "Revolutionary Road". Megan Fox and Shia LaBeouf stood fourth for two "Transformers" film.
Julia Roberts was sixth and seventh with George Clooney in the "Oceans 11" films and Richard Gere in "Runaway Bride" and "Pretty Woman".