Five people were killed in an accident involving a government bus and a car near Manapparai on Sunday in the district, police said.
All the victims were those travelling in the car. The accident happened on the Tiruchirappalli-Dindigul national highway after the car suffered a tyre burst and crashed into the bus.
The car was proceeding from Dindigul to Tiruchirappalli while the bus was on the opposite route.
Chief Minister M K Stalin expressed grief over the incident and announced cash relief to the families of the victims.
In a statement in Chennai, he announced Rs two lakh each to the families of the victims to be paid from the Chief Minister's Public Relief Fund.