Sent into bat, England were bowled out for 259 in the series-deciding third and final ODI on Sunday.
Skipper Jos Buttler top-scored with 60, while opener Jason Roy made 41.
For India, Hardik Pandya was the pick of the bowlers with figures of 4/24, while Yuzvendra Chahal picked up three wickets for 60.
Brief Scores:
England 259 all out in 45.5 overs (Jos Buttler 60, Jason Roy 41; Hardik Pandya 4/24, Yuzvendra Chahal 3/60).