The cocaine, reportedly from Costa Rica, was seized at the Peñas Blancas border crossing in southern Nicaragua, judicial support director Glenda Zavala and National Police spokeswoman Vilma Reyes said in a joint statement.
The narcotic was inside 50 packages containing candy and 250 bags of toys and were being transported in a van with Guatemalan number plate and a truck registered in Nicaragua.
The drivers fled when police began to inspect the vehicles, the officials said.