Murdoch was participating in a forum on the future of education at the Foundation for Excellence in Education, a non-profit organisation run by former governor of Florida Jeb Bush, yesterday.
Occupy Wall Street activists, many of whom were teachers, stood outside the San Francisco hotel and protested against Murdoch, an NBC report said.
A few protesters made their way inside the auditorium and interrupted his speech.
The protesters accused him of trying to make profit from the country's education system.
"Corporations own all the media in the world. Why should they not own all the education as well?" an activist said sarcastically.
Murdoch, however, remained unfazed by the demonstrations against him.
"It's OK, a little controversy makes everything more interesting," he said.
More than 100 protesters had gathered outside the hotel, protesting Murdoch's presence at the education conference.
'Occupy Wall Street' is an ongoing series of demonstrations in New York City against alleged social and economic inequality, corporate greed and the influence of corporate money and lobbyists on government, among other concerns. Similar demonstrations are being witnessed in a number of other cities as well.